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Mice will help reveal the roles of human brown fat

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Grownup mice have metabolically energetic, supraclavicular brown fats depots that share similarities with these in people. Credit score: Miao-Hsueh Chen, Baylor Faculty of Medication When it will get chilly round you, your physique turns up the warmth to take care of its regular temperature. The warmth is produced by brown adipose tissue, or brown fats, which additionally performs a job in how the physique makes use of glucose and fats. Nonetheless, scientists don't fully perceive how brown fats carries out its features each in well being and illness, partially due to the dearth of an applicable animal mannequin. In a paper revealed within the  Journal of Medical Investigation Perception , a crew of researchers from a number of establishments, together with Baylor Faculty of Medication, has stuffed this hole with the invention that mice even have brown fats deposits just like the most important depot present in individuals. The invention opens ...

Simple step to protect people with type 1 diabetes against heart disease

A small preliminary clinical trial published in Diabetes and Vascular Disease Research has found the easy step allows people with type 1 diabetes to better regulate their blood sugar levels. Crucially, it also reduces fat and inflammatory markers in the blood that can damage blood vessels and heart disease. People with type 1 diabetes are up to ten times more likely to suffer from cardiovascular disease than the general population, and the condition accounts for more than half of all deaths in this patient group. The team are now looking to continue with a larger trial over a longer period to look at blood vessel health and diabetes control. In the UK, most people with type 1 diabetes regulate their blood sugar levels by injecting insulin throughout the day. The dose after mealtimes is usually calculated from the amount of carbohydrate in the meal. But this doesn't account for how much fat is in the food, which is broken down by the body at a slower rate than carbohydrate. ...

Two interventions help improve weight management in children with overweight or obesity

More and more we recognize that, if we don't assist families in tackling the social and environmental conditions that impede their ability to make changes to their obesity-related behaviors, we will not be successful in pediatric weight management," says Elsie Taveras, MD, MPH, chief of General Pediatrics at MassGeneral Hospital for Children, who led the study. "To help us create our interventions we looked to families with children who had managed to improve their BMI, often under challenging environmental and social settings. These "positive outlier" families provided guidance on the content of health coaching, available resources in the community, language to use in motivating other families to change and the importance of building parents' confidence in taking on the challenge of reducing their child's excess weight." The Connect 4 Health trial was conducted from June 2014 through March 2016 at six Harvard Vanguard pediatric practices in th...